Fifteen people have died in a shooting at a primary school in Texas, says Governor Greg Abbott.
The 18-year-old gunman killed 14 students and one teacher at Robb Elementary School in the city of Uvalde.
The governor said the suspect was armed with a handgun and possibly a rifle in the attack.
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The public were asked to stay away as police investigate the crime scene.
Shootings at primary schools, where pupils range in age from five to 11, are still relatively rare.
The attack on Tuesday comes amid a national rise in gun violence.
Governor Abbott identified the attacker as a teenager, Salvador Ramos, who he said "shot and killed, horrifically, incomprehensibly, 14 students and killed a teacher".
"He himself is deceased, and it is believed that responding officers killed him," he added.
"It is believed that two responding officers were struck by rounds, but have no serious injuries."
The teen is also suspected of shooting his grandmother at the beginning of the rampage, law enforcement officials told CBS News, the BBC's partner in the US. Local media report he may have been a local high school student.
Uvalde Consolidated Independent School District Chief of Police Pete Arredondo said the shooting began at 11:32 local time, and that investigators believe the attacker "did act alone during this heinous crime".
The Uvalde Consolidated Independent School District - around 85 miles (135km) west of the city of San Antonio - told the BBC that students had been evacuated from the school. Just under 500 pupils are enrolled in the school.
Local hospitals disclosed that students from the school were being treated by emergency services.
A 66-year-old woman and a 10-year old girl are being treated at a hospital in San Antonio, and are both in a critical condition, University Health hospital officials say.
The Uvalde Memorial Hospital posted on Facebook that 13 children had been taken to hospital "via ambulances or buses".
Two "individuals" were dead when they arrived at hospital, the Facebook post said earlier. They are now planning to hold an "emergency blood drive" on Wednesday.
Uvalde Mayor Don McLaughlin told ABC News in a text message "this is a very bad situation".
The FBI is aiding in the investigation, according to CBS.
US President Joe Biden has been briefed on the attack, White House officials said, and is expected to deliver remarks later on Tuesday. Mr Biden also ordered that flags on the White House and other US federal buildings be flown at half-mast in honour of the victims in Uvalde.
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